Computational modelling in medicine

Several conceptual and computational models are currently under development. The following research directions and topics are planned:

Heart Rate Modeling

• Modeling of the optimal heart rate under resting and exercise conditions
• Submaximal exercise heart rate analysis
• Chronotropic adaptation and chronotropic incompetence
• Median-based versus mean-based heart rate analysis
• Histogram-based analysis of heart rhythm distributions and variability

Electrophysiology Models.

• Mathematical and dynamical models of pacemaker-mediated tachycardia (PMT) stability
• Stability analysis of supraventricular tachycardias (SVT)
• Graph-theoretical and network-based electrophysiological models
• Modeling of entrainment phenomena and stimulation dynamics
• Ventricular tachycardia (VT) exit-site modeling and substrate analysis

Physiological Systems.

• Investigation of physiological data in relation to environmental and climatic factors
• Biological rhythms and temporal physiological variability
• Thermodynamic and systems-based physiological models